The first settlers in Enterprise were Henry and Stephen Hales, who arrived in 1861. They found fertile land on the bench, but little water for irrigation. They dug a 2-mile ditch from the Weber River to water their farmland. A canal company was organized in 1863 to irrigate the whole area, but Enterprise was short on water for many years as thieves diverted water upstream. The first schoolhouse was built in 1863. A townsite with official blocks was surveyed and laid out in 1865. A sawmill operated in Roswell Canyon in the 1870s. Although it was not an official census precinct, the 1880 census enumerated 81 residents in Enterprise.

(Not to be confused with Enterprise, Utah in Washington County)